Leiden University (NL)

Leiden Institute of Chemistry
Principal investigator: 
Prof. Alexander Kros

The research of the Supramolecular & Biomaterials Chemistry group of Prof. Alexander Kros is focused in 3 areas; model systems for membrane fusion, new tools for drug delivery and supramolecular chemistry. For this, several interdisciplinary approaches are used ranging from peptide synthesis, self-assembly, biophysical characterization to in vitro and in vivo testing of the materials. Kros typically uses a bottom-up approach inspired by examples from Nature. Current research topics are: in vitro and in vivo membrane fusion of liposomes with live cells/zebrafish, hydrogels as a tool to enhance drug uptake in zebrafish larvae, giant unilamellar vesicles as nanoreactors, light-controlled drug release from mesoporous silica, peptide nanoparticle assembly.

The role in the MediSURF project will be the synthesis of liposomes and supported lipid bilayer coated mesoporous silica nanoparticles (MSN), functionalization of the exoskeleton with target moieties and biophysical characterization using a suite of techniques (CD, FTIR, fluorescence and confocal microscopy).