For decades, scientists have successfully made modifications to natural proteins to create engineered proteins with enhanced functions. With advances in protein design however, it is now possible to design and construct new and complex proteins, with advanced functionality, from the bottom up. MediSURF will lay the foundations for a new technological platform, in which de novo designed, nanoscale polypeptide skeletons (MAPS) will be precisely engineered from the bottom up.
Offering complete control over skeleton size and shape, as well as positioning and density of appended functionality, the potential of MAPS will be demonstrated by creating advanced cancer vaccines. Here, the ability to precisely control the periodic arrangement of bioactive reagents on the surface of the polypeptide skeleton is expected to trigger stronger and more predictable immune responses and could be a game changer in cancer immunology.